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Logistic costs heavily depend on the geography of the region and its transport accessibility. If it’s a large mountainous area, the transportation costs will be high in this region. There is a logistic coefficient for all regions in the game. Bear this in mind when considering directions for trading if you want to reduce the final price of the goods.
You can also influence the logistic costs directly. To do this, use an errand for the Minister of Industry in the government of the country you need. The "Develop road infrastructure” errand will reduce transportation costs.
You might use this tool if you want to influence the economies of countries at a deeper level.